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#106 De: Perez, Lorena (Stgo) <LPerez@munichre.com>
Enviado: Martes, 04 de Abril de 2000 02:43 p.m.
Asunto: Mortalidad en cardiologia
Buenos días:
Me gustaría saber si ustedes me pueden proporcionar la información de cual es la mortalidad en la Argentina por problemas cardíacos.
Desde ya muchas gracias,
Lorena Perez

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#107 De: Dr. Edgardo Schapachnik <edgardo@schapachnik.com.ar>
Enviado: Miercoles, 05 de Abril de 2000 10:04
Asunto: Sesion de Chat sobre Epidemiologia de los Factores de Riesgo
Queridos colegas:
Recuerdo a ustedes que el proximo viernes 14 de abril realizaremos una sesion de Chat academico sobre el tema Epidemiologia de los Factores de Riesgo, en el marco del Foro de Educacion Continua del Primer Congreso Virtual de Cardiologia.
Respondera preguntas el Dr. Mario Ciruzzi, medico cardiologo y epidemiologo del Hospital Pirovano de Buenos Aires.
Aquellos de ustedes que esten interesados en participar de esta sesion, asi como de las futuras que estan programadas, deberan requerir
informacion acerca del horario, servidor de chat y canal donde se llevara a cabo el evento, enviando un mail a
chat-pcvc@pcvc.sminter.com.ar
Recibiran ademas instrucciones sobre las reglas de netiquette que deberan respetarse en sesiones de esta naturaleza.
Quienes deseen suscribirse al FORO CHAT-PCVC y recibir informacion sobre las actividades de chat programadas para el anio 2000, asi como las sesiones de entrenamiento:
Enviar un mail a majordomo@pcvc.sminter.com.ar
con el siguiente comando:
subscribe chat-pcvc
Cordialmente
Edgardo

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#108 De: Dr. Edgardo Schapachnik <edgardo@schapachnik.com.ar>
Enviado: Miercoles, 05 de Abril de 2000 15:31
Asunto: Doxazosin y clortalidona
Queridos amigos:
En relacion al comentario que efectuara el dia 2 de abril, Gustavo Alcala referente al estudio ALLHAT, que comparo los resultados de usar Doxazosin y Clortalidona en pacienteds hipertensos, transcribo a continuacion el abstract del respectivo trabajo, publicado en el numero de hoy de la revista JAMA.
Pueden obtener el articulo completo en:
http://jama.ama-assn.org/issues/v283n15/full/joc00401.html
Espero lo disfruten y comenten en el Foro.
Un abrazo
Edgardo
===========================================================================
Vol. 283 No. 15, April 19, 2000
Original Contribution
JAMA-EXPRESS   
Major Cardiovascular Events in
Hypertensive Patients Randomized to
Doxazosin vs Chlorthalidone               
The Antihypertensive and Lipid-Lowering
Treatment to Prevent Heart Attack Trial
(ALLHAT)             
The ALLHAT Officers and Coordinators for the ALLHAT
Collaborative Research Group
Context 
Hypertension is associated with a significantly increased risk of morbidity and mortality. Only diuretics and -blockers have been shown to reduce this risk in long-term clinical trials.
Whether newer antihypertensive agents reduce the incidence of cardiovascular disease (CVD) is unknown.
Objective 
To compare the effect of doxazosin, an a-blocker, with chlorthalidone, a diuretic, on incidence of CVD in patients with hypertension as part of a
study of 4 types of antihypertensive drugs: chlorthalidone, doxazosin, amlodipine, and lisinopril.
Design 
Randomized, double-blind, active-controlled clinical trial, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, initiated in February 1994. In January 2000, after an interim analysis, an independent data review committee recommended discontinuing the doxazosin treatment arm based on comparisons with chlorthalidone. Therefore, outcomes data presented herein reflect follow-up through December 1999.
Setting 
A total of 625 centers in the United States and Canada.
Participants 
A total of 24,335 patients (aged 55 years) with hypertension and at least 1 other coronary heart disease (CHD) risk factor who received either
doxazosin or chlorthalidone.
Interventions 
Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n=15,268), or doxazosin, 2 to 8 mg/d (n=9067), for a planned
follow-up of 4 to 8 years.
Main Outcome Measures 
The primary outcome measure was fatal CHD or nonfatal myocardial infarction (MI), analyzed by intent to treat; secondary outcome measures included all-cause mortality, stroke, and combined CVD (CHD death, nonfatal MI, stroke, angina, coronary revascularization, congestive heart failure [CHF], and peripheral arterial disease); compared by the chlorthalidone group vs the doxazosin group.
Results 
Median follow-up was 3.3 years. A total of 365 patients in the doxazosin group and 608 in the chlorthalidone group had fatal CHD or nonfatal MI, with no difference in risk between the groups (relative risk [RR], 1.03; 95% confidence interval [CI], 0.90-1.17; P=.71). Total mortality did not differ between the doxazosin and chlorthalidone arms (4-year rates, 9.62% and 9.08%, respectively; RR, 1.03; 95% CI, 0.90-1.15; P=.56.) The doxazosin arm, compared with the chlorthalidone arm, had a higher risk of stroke (RR, 1.19; 95% CI, 1.01-1.40; P=.04) and combined CVD (4-year rates, 25.45% vs 21.76%; RR, 1.25; 95% CI, 1.17-1.33; P<.001). Considered separately, CHF risk was doubled (4-year rates, 8.13% vs 4.45%; RR, 2.04; 95% CI, 1.79-2.32; P<.001); RRs for angina, coronary revascularization, and peripheral arterial disease were 1.16 (P<.001), 1.15 (P=.05), and
.07 (P=.50), respectively.
Conclusion 
Our data indicate that compared with doxazosin, chlorthalidone yields essentially equal risk of CHD death/nonfatal MI but significantly reduces
the risk of combined CVD events, particularly CHF, in high-risk hypertensive patients.
JAMA. 2000;283:1967-1975

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#109 De: Dr. Edgardo Schapachnik <edgardo@schapachnik.com.ar>
Enviado: Viernes, 07 de Abril de 2000 14:01
Asunto: Actualizacion bibliografica
Queridos amigos:
Estas son las citas bibliograficas sobre TABACO aparecidas en Medline esta semana.
Un abrazo
Edgardo
*************************************************************************
Paper #1
10750909 Granger CL, et al.
Microtubule reorganization in tobacco BY-2 cells stably expressing GFP-MBD.
Planta. 2000 Feb;210(3):502-9.
[MEDLINE record in process]
PMID: 10750909; UI: 20212961.
________________________________________
Paper #2
10750903 Mesnard F, et al.
Use of 15N reverse gradient two-dimensional nuclear magnetic resonance spectroscopy to follow metabolic activity in Nicotiana plumbaginifolia cell-suspension cultures.
Planta. 2000 Feb;210(3):446-53.
[MEDLINE record in process]
PMID: 10750903; UI: 20212955.
________________________________________
Paper #3
10750895 Hausler RE, et al.
Control of carbon partitioning and photosynthesis by the triose phosphate/phosphate translocator in transgenic tobacco plants (Nicotiana
tabacum). II. Assessment of control coefficients of the triose phosphate/phosphate translocator.
Planta. 2000 Feb;210(3):383-90.
[MEDLINE record in process]
PMID: 10750895; UI: 20212947.
________________________________________
Paper #4
10750894 Hausler RE, et al.
Control of carbon partitioning and photosynthesis by the triose phosphate/phosphate translocator in transgenic tobacco plants (Nicotiana
tabacum L.). I. Comparative physiological analysis of tobacco plants with antisense repression and overexpression of the triose phosphate/phosphate translocator.
Planta. 2000 Feb;210(3):371-82.
[MEDLINE record in process]
PMID: 10750894; UI: 20212946.
________________________________________
Paper #5
10750662 van Oijen MG, et al.
Oral field cancerization: carcinogen-induced independent events or micrometastatic deposits?
Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):249-56.
[MEDLINE record in process]
PMID: 10750662; UI: 20212700.
________________________________________
Paper #6
10750601 Launoy G, et al.
Tobacco type and risk of squamous cell cancer of the oesophagus in males: a French multicentre case-control study.
Int J Epidemiol. 2000 Feb;29(1):36-42.
[MEDLINE record in process]
PMID: 10750601; UI: 20212639.
________________________________________
Paper #7
10750515 Odek-Ogunde M, et al.
Prevalence of substance use among students in a Kenyan University: a preliminary report.
East Afr Med J. 1999 Jun;76(6):301-7.
[MEDLINE record in process]
PMID: 10750515; UI: 20214099.
________________________________________
Paper #8
10750321 Green BE, et al.
Marijuana use and depression.
J Health Soc Behav. 2000 Mar;41(1):40-9.
[MEDLINE record in process]
PMID: 10750321; UI: 20213905.
________________________________________
Paper #9
10749368 Repka V, et al.
Induction and distribution of amylolytic activity in Cucumis sativus L. in response to virus infection.
Acta Virol. 1999 Aug;43(4):227-35.
[MEDLINE record in process]
PMID: 10749368; UI: 20210939.
________________________________________
Paper #10
10749322 Breuer-Katschinski B, et al.
Alcohol and cigarette smoking and the risk of colorectal adenomas.
Dig Dis Sci. 2000 Mar;45(3):487-93.
[MEDLINE record in process]
PMID: 10749322; UI: 20210893.
________________________________________
Paper #11
10748657 Fuentealba R, et al.
[No title available].
Rev Panam Salud Publica. 2000 Feb;7(2):79-87. Spanish.
[MEDLINE record in process]
PMID: 10748657; UI: 20212145.
________________________________________
Paper #12
10748530 Lopez-Bucio J, et al.
Enhanced phosphorus uptake in transgenic tobacco plants that overproduce citrate.
Nat Biotechnol. 2000 Apr;18(4):450-453.
[Record as supplied by publisher]
PMID: 10748530.
________________________________________
Paper #13
10748528 Zubko E, et al.
Intrachromosomal recombination between attP regions as a tool to remove selectable marker genes from tobacco transgenes.
Nat Biotechnol. 2000 Apr;18(4):442-445.
[Record as supplied by publisher]
PMID: 10748528.
________________________________________
Paper #14
10747941 Locatelli F, et al.
The product of the rice myb7 unspliced mRNA dimerizes with the maize leucine zipper Opaque2 and stimulates its activity in transient
expression assay.
J Biol Chem. 2000 Mar 22;.
[Record as supplied by publisher]
PMID: 10747941.
________________________________________
Paper #15
10747072 Carels N, et al.
Two Classes of Genes in Plants.
Genetics. 2000 Apr;154(4):1819-1825.
[Record as supplied by publisher]
PMID: 10747072.
________________________________________
Paper #16
10747034 Lucy AP, et al.
Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus.
EMBO J. 2000 Apr 3;19(7):1672-1680.
[Record as supplied by publisher]
PMID: 10747034.
________________________________________
Paper #17
10746938 Waalkes MP, et al.
Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats.
Toxicol Sci. 2000 Mar;54(1):110-20.
[MEDLINE record in process]
PMID: 10746938; UI: 20208727.
________________________________________
Paper #18
10746752 Hickey CA, et al.
Low prenatal weight gain among adult WIC participants delivering term singleton infants: variation by maternal and program participation
characteristics.
Matern Child Health J. 1999 Sep;3(3):129-40.
[MEDLINE record in process]
PMID: 10746752; UI: 20208541.
________________________________________
Paper #19
10746386 Eide AH, et al.
Adolescent drug use in Zimbabwe assessed by their teachers.
Cent Afr J Med. 1999 Apr;45(4):80-5.
[MEDLINE record in process]
PMID: 10746386; UI: 20210481.
________________________________________
Paper #20
10745972 [No authors listed]
Diagnosis, management and prevention of the common dyslipidaemias in South Africa--clinical guideline, 2000. South African Medical Association and Lipid and Atherosclerosis Society of Southern Africa Working Group.
S Afr Med J. 2000 Feb;90(2 Pt 2):164-74, 176-8.
[MEDLINE record in process]
PMID: 10745972; UI: 20210067.
________________________________________
Paper #21
10745650 Miller N, et al.
Trends in chronic obstructive pulmonary disease mortality.
Mo Med. 2000 Mar;97(3):87-90.
[MEDLINE record in process]
PMID: 10745650; UI: 20209737.
________________________________________
Paper #22
10745643 Borum ML.
A comparison of smoking cessation efforts in African Americans by resident physicians in a traditional and primary care internal medicine
residency.
J Natl Med Assoc. 2000 Mar;92(3):131-5.
[MEDLINE record in process]
PMID: 10745643; UI: 20209730.
________________________________________
Paper #23
10745173 Mahale A, et al.
Microsatellite alterations on chromosome 9 in chewing tobacco-induced oral squamous cell carcinomas from India.
Oral Oncol. 2000 Mar 1;36(2):199-206.
[Record as supplied by publisher]
PMID: 10745173.
________________________________________
Paper #24
10745171 Kannan K, et al.
FHIT Gene mutations and single nucleotide polymorphism in Indian oral and cervical squamous cell carcinomas.
Oral Oncol. 2000 Mar 1;36(2):189-193.
[Record as supplied by publisher]
PMID: 10745171.
________________________________________
Paper #25
10745168 Moreno-Lopez LA, et al.
Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case-control study in Madrid, Spain.
Oral Oncol. 2000 Mar 1;36(2):170-174.
[Record as supplied by publisher]
PMID: 10745168.
________________________________________
Paper #26
10744635 Wilson MH, et al.
Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction.
FASEB J. 2000 Apr;14(5):791-796.
[Record as supplied by publisher]
PMID: 10744635.
________________________________________
Paper #27
10744021 Hudak KA, et al.
A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.
RNA. 2000 Mar;6(3):369-80.
[MEDLINE record in process]
PMID: 10744021; UI: 20205888.
________________________________________
Paper #28
10743909 Frosch DL, et al.
Associations between tobacco smoking and illicit drug use among methadone-maintained opiate-dependent individuals.
Exp Clin Psychopharmacol. 2000 Feb;8(1):97-103.
[MEDLINE record in process]
PMID: 10743909; UI: 20205776.
________________________________________
Paper #29
10743908 Wetter DW, et al.
Tobacco withdrawal signs and symptoms among women with and without a history of depression.
Exp Clin Psychopharmacol. 2000 Feb;8(1):88-96.
[MEDLINE record in process]
PMID: 10743908; UI: 20205775.
________________________________________
Paper #30
10743907 Taylor RC, et al.
Tobacco craving: intensity-related effects of imagery scripts in drug abusers.
Exp Clin Psychopharmacol. 2000 Feb;8(1):75-87.
[MEDLINE record in process]
PMID: 10743907; UI: 20205774.
________________________________________
Paper #31
10743656 Iglesias VA, et al.
Movement of plant viruses is delayed in a beta-1,3-glucanase-deficient mutant showing a reduced plasmodesmatal size exclusion limit and enhanced callose deposition.
Plant J. 2000 Jan;21(2):157-66.
[MEDLINE record in process]
PMID: 10743656; UI: 20208059.
________________________________________
Paper #32
10743368 Chelleng PK, et al.
Risk factors for cancer nasopharynx: a case-control study from Nagaland, India.
Natl Med J India. 2000 Jan-Feb;13(1):6-8.
[MEDLINE record in process]
PMID: 10743368; UI: 20207771.
________________________________________
Paper #33
10742926 Plummer HK 3rd, et al.
Interaction of tobacco-specific toxicants with nicotinic cholinergic regulation of fetal pulmonary neuroendocrine cells: implications for
pediatric lung disease.
Exp Lung Res. 2000 Mar;26(2):121-35.
[MEDLINE record in process]
PMID: 10742926; UI: 20207329.
________________________________________
Paper #34
10742713 Zayas RM, et al.
Neurons involved in nitric oxide-mediated cGMP signaling in the tobacco hornworm, Manduca sexta.
J Comp Neurol. 2000 Apr;419(4):422-438.
[Record as supplied by publisher]
PMID: 10742713.
________________________________________
Paper #35
10742645 McDonald CA, et al.
Intentions to quit smoking in substance-abusing teens exposed to a tobacco program.
J Subst Abuse Treat. 2000 Apr 1;18(3):291-308.
[Record as supplied by publisher]
PMID: 10742645.
________________________________________
Paper #36
10742373 Froen JF, et al.
Adverse Effects of Nicotine and Interleukin-1beta on Autoresuscitation After Apnea in Piglets: Implications for Sudden Infant Death Syndrome.
Pediatrics. 2000 Apr;105(4):E52.
[Record as supplied by publisher]
PMID: 10742373.
________________________________________
Paper #37
10741992 Zinn C.
Australia to consider a class action against tobacco industry.
BMJ. 2000 Apr 1;320(7239):894A.
No abstract available.
[Record as supplied by publisher]
PMID: 10741992.
________________________________________
Paper #38
10741991 Gottlieb S.
Supreme Court rules that FDA cannot regulate tobacco industry.
BMJ. 2000 Apr 1;320(7239):894.
No abstract available.
[Record as supplied by publisher]
PMID: 10741991.
________________________________________
Paper #39
10741540 Neumark YD, et al.
&quot;Alcohol dependence&quot; and death: survival analysis of the baltimore ECA sample from 1981 to 1995.
Subst Use Misuse. 2000 Mar;35(4):533-49.
[MEDLINE record in process]
PMID: 10741540; UI: 20203584.
________________________________________
Paper #40
10741536 Beconia E, et al.
Smoking cessation treatments in Spain. A thirty-year perspective:
1966-1996.
Subst Use Misuse. 2000 Mar;35(4):433-49.
[MEDLINE record in process]
PMID: 10741536; UI: 20203580.
________________________________________
Paper #41
10741216 Courtwright DT.
Medicine's problem children: tobacco, alcohol, and amphetamines.
Trans Stud Coll Physicians Phila. 1999 Dec;21:59-86.
No abstract available.
[MEDLINE record in process]
PMID: 10741216; UI: 20205389.
________________________________________
Paper #42
10740940 Palfai TP, et al.
Effects of nicotine deprivation on alcohol-related information processing and drinking behavior.
J Abnorm Psychol. 2000 Feb;109(1):96-105.
[MEDLINE record in process]
PMID: 10740940; UI: 20205113.
________________________________________
Paper #43
10740661 Westmaas JL, et al.
Contemporary smoking cessation.
Cancer Control. 2000 Jan-Feb;7(1):56-62.
[MEDLINE record in process]
PMID: 10740661; UI: 20204834.
________________________________________
Paper #44
10740203 Milunsky A, et al.
A tobacco-specific carcinogen in the fetus.
Prenat Diagn. 2000 Apr;20(4):307-310.
[Record as supplied by publisher]
PMID: 10740203.
________________________________________

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