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Cortisol Evolution in Interventions with
Extracorporeal Circulation

Rodríguez, Justino; Corona, Pedro;
Pérez, Miguel Angel; Pérez, José Luis;
Morillas, Mª. Consolación.

Intensive Medical Unit. Clinica "San Roque". Las Palmas G.C.
Intensive Medical Unit. Hospital Militar Central "Gómez Ulla".
Madrid. España

Objective: To study the variations of the levels of the cortisol in interventions with extracorporeal circulation (CEC) during a period of 5 days.

Methods: A prospective study, without randomiser, selecting 50 patients. 25 with cardiac valvular substitution (RVC), 11 males and 14 females, and 25 patients with aortocoronary bypass (BP), all males. They are excluded those that present clinical or analytically plasma cortisol levels low or high. They were carried out 5 takings of blood. On 1st, the previous day to the surgery; on 2nd, during the CEC, in the moment of maximum hypothermia; on 3rd, to the arrival to the unit medical intensive; on 4th, the following day of the surgery; on 5th, five days later of surgery. The method statistical employee was the Test t Student among the different extractions accepting as significant the values from lowers than p to 0.05.

Results: The results of the different takings were of 194.46 ± 139.78, 122.08 ± 120.9, 243.64 ± 239.74, 527.42 ± 305.15 and 381.23 ± 176.09. The statistical analysis demonstrated a decrease significant initial (p = 0.005) followed by significant increases of the values during and 1st day of the intervention (p = 0.001 and p = 0.00001). However, the values descended later from significant way (p = 0.002,) although they were significantly high with respect to the initial values (p = 0.00001).

Conclusions: A significant descent of the cortisol exists during a CEC. However, it increases very significantly in an immediate way after the same one reaching the maximum on 1st day spreading to the normalisation on 5th day, being even high.



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2nd Virtual Congress of Cardiology

Dr. Florencio Garófalo
Steering Committee
Dr. Raúl Bretal
Scientific Committee
Dr. Armando Pacher
Technical Committee - CETIFAC

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