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Cardiac Autonomic Function Evaluation,
Using Temporal Analysis of Heart Rate
Variability, in Human Immunodeficiency
Virus (Hiv) Infected Patients

Jesus, Paulo César; Araujo, Dourado Daniel;
de Deus, Passos Mauro; Moreira, Alves Luciano;
Silva, Antonio Emmanuel;
Junqueira Júnior; Luiz Fernando

University of Brasilia, Brasilia, Brazil

Introduction: The Autonomic Nervous System modulates mechanical and electrophysiological properties of the heart. Some HIV infected patients present postural hypotension and syncope, that may be consequence of cardiac autonomic dysfunction.

Objective: We aim to evaluate autonomic cardiac function, by means of temporal analysis of Heart Rate Variability (HRV) (short term analysis), in HIV infected patients (HIVip), using specific autonomic procedures, in comparison with healthy volunteers (NL).

Individuals and Methods: The electrocardiogram was registered during 5 minutes, in supine (vago-sympathetical balance) and active orthostatic posture (sympathetic stimulus), and cold face test (parasympathetic stimulus). HRV was analyzed using a specific software developed at Cardiovascular Laboratory (University of Brasilia). The following parametrical temporal indexes were analyzed: Mean of RR intervals (RRmean) and Standard Deviation of the mean (SD). Both groups were compared by Mann-Whitney test (p<0,05).

Results: We studied 49 volunteers, 18 of HIVip (11 male and 7 female) and 31 healthy volunteers (19 male and 12 female); mean (±sd) age were 33,6 (±10,3) and 28,8 (±8,7) years, respectively. Table 1 (below) shows the median values of temporal indexes obtained in both groups (HIVip and NL), in the three experimental situations.

Conclusion: Our data demonstrate that HIV infected patients, in comparison with healthy volunteers, present significant autonomic cardiac dysfunction (reduction of parasympathetic activity and/or increase in sympathetic activity on the heart).



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2nd Virtual Congress of Cardiology

Dr. Florencio Garófalo
Steering Committee
Dr. Raúl Bretal
Scientific Committee
Dr. Armando Pacher
Technical Committee - CETIFAC

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